Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19.
Identifieur interne : 000848 ( 2020/Analysis ); précédent : 000847; suivant : 000849Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19.
Auteurs : Anuj Sharma [États-Unis]Source :
- Microbes and infection [ 1769-714X ] ; 2020.
Abstract
Coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL), antimalarial drugs, have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. CHL/HCHL have anti-inflammatory activity and are used to treat rheumatoid arthritis, osteoarthritis and lupus. Although, CHL/HCHL have an anti-viral activity against several viruses in cell-cultures, the anti-viral activity in-vivo is questionable. Repurposing of CHL/HCHL to treat SARS-CoV-2 infection is appealing. However, there is empirical evidence from animal studies with other viruses suggesting that CHL/HCHL may have an untoward paradoxical effect. One thus cannot exclude the possibility that CHL may increase the severity of the disease and prove deleterious both for the patients and public health efforts to contain the highly contagious and explosive spread of SARS-CoV-2.
DOI: 10.1016/j.micinf.2020.04.004
PubMed: 32305500
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000033
- to stream PubMed, to step Curation: 000033
- to stream PubMed, to step Checkpoint: 000670
- to stream Ncbi, to step Merge: 003B68
- to stream Ncbi, to step Curation: 003B68
- to stream Ncbi, to step Checkpoint: 003B68
- to stream Main, to step Merge: 000848
- to stream Main, to step Curation: 000848
- to stream Main, to step Exploration: 000848
- to stream 2020, to step Extraction: 000848
Links to Exploration step
pubmed:32305500Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19.</title><author><name sortKey="Sharma, Anuj" sort="Sharma, Anuj" uniqKey="Sharma A" first="Anuj" last="Sharma">Anuj Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814. Electronic address: anuj.sharma.ctr@usuhs.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32305500</idno><idno type="pmid">32305500</idno><idno type="doi">10.1016/j.micinf.2020.04.004</idno><idno type="wicri:Area/PubMed/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000033</idno><idno type="wicri:Area/PubMed/Curation">000033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000033</idno><idno type="wicri:Area/PubMed/Checkpoint">000670</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000670</idno><idno type="wicri:Area/Ncbi/Merge">003B68</idno><idno type="wicri:Area/Ncbi/Curation">003B68</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B68</idno><idno type="wicri:Area/Main/Merge">000848</idno><idno type="wicri:Area/Main/Curation">000848</idno><idno type="wicri:Area/Main/Exploration">000848</idno><idno type="wicri:Area/2020/Extraction">000848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19.</title><author><name sortKey="Sharma, Anuj" sort="Sharma, Anuj" uniqKey="Sharma A" first="Anuj" last="Sharma">Anuj Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814. Electronic address: anuj.sharma.ctr@usuhs.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><series><title level="j">Microbes and infection</title><idno type="eISSN">1769-714X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL), antimalarial drugs, have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19. CHL/HCHL have anti-inflammatory activity and are used to treat rheumatoid arthritis, osteoarthritis and lupus. Although, CHL/HCHL have an anti-viral activity against several viruses in cell-cultures, the anti-viral activity in-vivo is questionable. Repurposing of CHL/HCHL to treat SARS-CoV-2 infection is appealing. However, there is empirical evidence from animal studies with other viruses suggesting that CHL/HCHL may have an untoward paradoxical effect. One thus cannot exclude the possibility that CHL may increase the severity of the disease and prove deleterious both for the patients and public health efforts to contain the highly contagious and explosive spread of SARS-CoV-2.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sharma, Anuj" sort="Sharma, Anuj" uniqKey="Sharma A" first="Anuj" last="Sharma">Anuj Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000848 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd -nk 000848 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= 2020
|étape= Analysis
|type= RBID
|clé= pubmed:32305500
|texte= Chloroquine Paradox May Cause More Damage Than Help Fight COVID-19.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/2020/Analysis/RBID.i -Sk "pubmed:32305500" \
| HfdSelect -Kh $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |